Graham Potter's Chelsea have been paired with Champions League holders Real Madrid in the quarter-finals, while Pep Guardiola faces a reunion with former club Bayern Munich for Manchester City.
Both Premier League sides will meet each other in the semi-final, should both Chelsea and City advance through their last-eight ties.
Meanwhile, there will be an all-Italian derby in the quarter-finals as Serie A champions AC Milan face current leaders Napoli, while Inter Milan will take on Benfica.